Epigenetics, Autism Spectrum, and Neurodevelopmental Disorders
نویسندگان
چکیده
منابع مشابه
Epigenetics of autism spectrum disorders.
The autism spectrum disorders (ASD) comprise a complex group of behaviorally related disorders that are primarily genetic in origin. Involvement of epigenetic regulatory mechanisms in the pathogenesis of ASD has been suggested by the occurrence of ASD in patients with disorders arising from epigenetic mutations (fragile X syndrome) or that involve key epigenetic regulatory factors (Rett syndrom...
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Epigenetic mechanisms are essential for normal development during embryogenesis and for differentiation of neural cells. Thus, precise understanding of epigenetic mechanisms, including DNA methylation and histone modification, is important to elucidate the pathogenic pathways in neurodevelopmental disorders. These include various congenital disorders caused by failures of genomic imprinting, X ...
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Within research into neurodevelopmental disorders, little is known about the mechanisms underpinning changes in symptom severity across development. When the behavioural presentation of a condition improves/symptoms lessen, this may be because core underlying atypicalities in cognition/neural function have ameliorated. An alternative possibility is 'compensation'; that the behavioural presentat...
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Previous models or hypotheses of autism spectral disorder (ASD) failed to take into full consideration the chronological and causal developmental trajectory, leading to the emergence of diverse phenotypes through a complex interaction between individual etiologies and environmental factors. Those phenotypes include persistent deficits in social communication and social interaction (criteria A i...
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Objective: The present study has been carried out to compare the social competence in two groups of students with Autism Disorder (AD) and Learning Disorders (LD). Methods: This research was a kind of descriptive research with 2 comparative groups. 90 learning and Autistic disorder students aged 10 to 13 years (45 LD & 45 AD) were selected randomly as a statistical sample. For the assessment...
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ژورنال
عنوان ژورنال: Neurotherapeutics
سال: 2013
ISSN: 1933-7213,1878-7479
DOI: 10.1007/s13311-013-0227-0